parathyroid adenoma [MEN1 mutation]

Substantial number of parathyroid adenomas not associated with MEN-1 syndrome are associated with somatic mutations & loss of heterozygosity at chromosome 11q13.

Properties

GENETIC-ABNORMALITY: mutation LOCUS: human chromosome-11 Q13 ABERRANT-GENE: MEN1 gene

References

Heppner et al. Nature Genetics 16:375-8, 1997